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    Tuesday, July 11, 2017

    Risks of taking IBUPROFEN..







    webmd.com

    FDA Strengthens Warning on NSAIDs and Heart Risk

    Popular painkillers like ibuprofen and naproxen have carried warnings for years about potential risks of heart attacks and strokes. This week, the FDA decided to strengthen those warnings on the medications, known as non steroidal anti-inflammatory drugs, or NSAIDs.

    The warning includes both prescription and over-the-counter versions of drugs. It emphasizes that the risk applies to even short-term use of medications like Advil, Aleve, and Motrin. And it’s true for people with or without heart disease.

    Guardian.com
    Calls for ibuprofen sale restrictions after study finds cardiac arrest risk
    There have been fresh calls for restrictions on the sale of the painkiller ibuprofenafter another study found it heightens the risk of cardiac arrest.

    Taking the over-the-counter drug was associated with a 31% increased risk, researchers in Denmark found.

    Other medicines from the same group of painkillers, known as non-steroidal anti-inflammatory drugs (NSAIDs), presented an even higher risk, according to the findings published on Wednesday in the European Heart Journal.

    Diclofenac, available over the counter in the UK until 2015 and still taken on prescription, raised the risk by 50%.

    thesun.co.uk

    PAIN KILLER Taking ibuprofen to treat pain ‘for just ONE DAY increases your risk of heart attack by half’
    They include popular over-the-counter pills such as ibuprofen, and prescription-only drugs such as diclofenac.

    Both are taken by millions for conditions such as headaches, back pain and arthritis.

    The study, published in The BMJ, said their effect on heart attack risk was almost immediate.

    But it was not long-lasting and wore off over time.

    Past studies have found the common painkillers increase risk of cardiac arrest by up to a third.

    Scientists fear the drugs may cause blood vessels to narrow, increase fluid retention and alter blood pressure.

    Canadian experts found taking any regular dose of ibuprofen for between one to seven days raised chances by 48 per cent.

    For diclofenac it went up 50 per cent, and naproxen 53 per cent.

    Taking stronger pills was more dangerous, but using the painkillers for longer than a month did not greatly alter risk.













    1 comment:

    1. Tramadol is used similarly to codeine, to treat moderate to moderately severe pain. Tramadol is somewhat pharmacologically similar to levorphanol (albeit with much lower μ-agonism), as both opioids are also NMDA-antagonists which also have SNRI activity (other such opioids to do the same are dextropropoxyphene (Darvon) & M1-like molecule tapentadol (Nucynta, a new synthetic atypical opioid made to mimic the agonistic properties of tramadol's metabolite, M1(O-Desmethyltramadol). Tramadol is also molecularly similar to venlafaxine (Effexor) and has similar SNRI effects, with antinociceptive effects also observed.

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